Active von Willebrand Factor in patients with a bleeding diathesis
نویسندگان
چکیده
منابع مشابه
Platelet von Willebrand factor in inherited and acquired bleeding disorders.
The majority of plasma proteins involved in the mechanisms of hemostasis are loosely adsorbed on the platelet surface. A few of them, however, can also be measured in washed platelets, in which they are contained in the intracellular organelles called a granules. The main proteins involved in blood coagulation concentrated in platelets are von Willebrand factor (vWF), fibrinogen, and factor V. ...
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End-stage renal disease patients, particularly those treated with hemodialysis (HD), suffer from complex hemostatic disorders. Patients with uremia may experience two opposite he‐ mostatic complications: bleeding diathesis and thrombotic tendencies. Bleeding diathesis in uremic patients is primarily seen due to abnormalities in primary hemostasis, particularly platelet function disorder and imp...
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OBJECTIVE von Willebrand Factor (vWF) structure-function relationship has been studied only in vitro. To investigate the physiological importance of particular vWF domains, we have introduced mutations into murine vWF (mvWF) cDNA inhibiting vWF binding to glycoprotein (Gp) Ib, GpIIbIIIa, and to fibrillar collagen. METHODS AND RESULTS We delivered wild-type (WT) or mutant mvWF cDNA into vWF-de...
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Hemostasis and thrombosis represent two sides of the same coin. Hemostasis maintains blood fluidity in the vascular system while allowing for rapid thrombus formation to prevent excessive hemorrhage after blood vessel injury. Thrombosis is a pathologic extension of the normal hemostatic mechanism, occurring when unwanted clot formation develops in certain pathological situations. The molecular ...
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Several plasma-derived intermediate and high-purity concentrates containing von Willebrand factor (VWF) and factor VIII (FVIII) are currently available. The main role of these products in the management of the pediatric population is represented by the replacement therapy in patients with severe or intermediate forms of von Willebrand disease, in whom other treatments are ineffective or contrai...
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ژورنال
عنوان ژورنال: Thrombosis Update
سال: 2020
ISSN: 2666-5727
DOI: 10.1016/j.tru.2020.100001